الخميس , أغسطس 18 2022
الرئيسية / أرشيف الوسم : ACTIVITY

أرشيف الوسم : ACTIVITY

SYNTHESIS OF NOVEL 2- 1-( 4-METHYLPIPERAZINYL) NICOTINAMIDE DERIVATIVE OF ANTITUMOR ACTIVITY

A NOVEL 2-(1-(4-METHYLPIPERAZINYL)]NICOTINAMIDE DERIVATIVE 5 WAS SYNTHESIZED THROUGH AROMATIC NUCLEOPHILIC SUBSTITUTION REACTION OF 4-METHYLPIPERA/INE WITH 2-BROMONICOTINAMIDE ANALOGUE 4 THE LATTER WAS OBTAINED VIA BROMINATION OF 2-CYANO-A’-PHENYLPENTAMIDE DERIVATIVE 3 IN GLAEIAL ACETIC ACID. MOREOVER, PENTAMIDE 3 WAS PREPARED THROUGH BASE-CATALYZED MICHAEL ADDITION REACTION OF CYANACETANILIDE 2 TO CHALCONC 1 IN REFLUXING ABSOLUTE ETHANOL. ANTITUMOR PROPERTIES OF 5 UTILIZE 59 DIFFERENT HUMAN …

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